Logo der KFO 142 Logo Banner Logo Banner Logo Banner Logo Banner Logo Uni Ulm
Language: Deutsch I English English Sites
Stadt Ulm, Deutschland

Spokesperson

Prof. Dr. Karin Scharffetter-Kochanek
Klinik für Dermatologie und Allergologie
Albert-Einstein-Allee 23
89081 Ulm


Head

Prof. Dr. Hartmut Geiger
Klinik für Dermatologie und Allergologie
Universität Ulm
James Franck-Ring 11c
89081 Ulm


Project 2

The role of DNA-damage and repair in different clinical stages of aging: Investigation of functional relevance and prophylactic/therapeutic intervention

One natural consequence of aging is the continuous accumulation of damages in the genetic material. This damage occurs in both the nuclear and mitochondrial (mt) DNA. The central roles of mitochondrial mutations in aging, as well as DNA repair mechanisms which protect from these mutations, are well-established. Therefore, premature aging diseases (progeroid syndromes) with defective DNA repair are important model systems for aging research. In the first funding period of this clinical research group, we demonstrated that in Cockayne syndrome (CS), an important progeroid syndrome, the proteins CSA and CSB are absent in the nucleus and in the mitochondria, whereas they are present in healthy individuals.

One natural consequence of aging is the continuous accumulation of damages in the genetic material. This damage occurs in both the nuclear and mitochondrial (mt) DNA. The central roles of mitochondrial mutations in aging, as well as DNA repair mechanisms which protect from these mutations, are well-established. Therefore, premature aging diseases (progeroid syndromes) with defective DNA repair are important model systems for aging research. In the first funding period of this clinical research group, we demonstrated that in Cockayne syndrome (CS), an important progeroid syndrome, the proteins CSA and CSB are absent in the nucleus and in the mitochondria, whereas they are present in healthy individuals.

Additionally, these results demonstrate that it is possible to retard aging-associated processes with therapeutic strategies employing anti-oxidants. Future in vitro experiments will utilize cell culture models to clarify: (i) the mechanism of CSA and CSB transport into mitochondria, (ii) the molecular function of CSA and CSB and their interactions with other proteins, (iii) as well as the relevance of mitochondrial CSA and CSB in comparison with nuclear processes. Additionally, in vivo experiments will examine (iv) how various antioxidants protect from aging processes using a special rapid aging murine model, which is defective in nuclear and/or mitochondrial DNA repair.

Chief Investigator

Mark Berneburg, M.D.
Department of Dermatology
Eberhard Karls University
Liebermeisterstrasse 25
72076 Tuebingen
Germany

Phone: +49-(0)-7071-298 0869 (Office)
Phone: +49-(0)-7071-298 4591 (Photo therapy)
Fax: +49-(0)-7071-29 5623
mark.berneburg[at]med.uni-tuebingen.de

References

List of publications from:
Mark Berneburg
>> Pubmed


© dw-websites   -   Home   I   Contact   I   Imprint