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Stadt Ulm, Deutschland


Prof. Dr. Karin Scharffetter-Kochanek
Klinik für Dermatologie und Allergologie
Albert-Einstein-Allee 23
89081 Ulm


Prof. Dr. Hartmut Geiger
Klinik für Dermatologie und Allergologie
Universität Ulm
James Franck-Ring 11c
89081 Ulm

Project 3

Importance of altered transcriptional control in premature aging and aging in general

In this funding period, we will continue to advance our previous work investigating the correlation between premature aging diseases as aging model systems and basal transcription mechanisms. As our earlier analyses focused on RNA polymerase I transcription, in the next funding period we will investigate the function of the Werner syndrome protein (WRN) on gene expression mediated by RNA polymerase II transcription, identify WRN-dependent genes and elucidate the relevance of these genes for the aging process.

Using TFIIH mutant Cockayne syndrome cells, we can clarify and demonstrate the function of TFIIH in RNA polymerase I-mediated transcription, and if a general disruption of ribosomal biogenesis is involved (has a role) in the early aging phenotype observed in this premature aging syndrome. Further experiments should clarify if the function of RNA polymerase I transcription and the nucleolus as a cellular stress sensor also influence the resulting cellular responses such as apoptosis and senescence. Additionally, apoptosis and senescence models such as Cockayne syndrome and stress-induced senescence in PUVA-treated fibroblasts will be investigated and RNA polymerase I transcription will be manipulated in order to be able to analyze the effects on cellular responses.

Chief Investigator

Dr. Sebastian Iben
University of Ulm
Life Science Building, N27
89081 Ulm

Phone: +49 (0)731 500 57645
Fax: +49 (0)731 500 46110


List of publications from:
Sebastian Iben
>> Pubmed

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