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Stadt Ulm, Deutschland

Spokesperson

Prof. Dr. Karin Scharffetter-Kochanek
Klinik für Dermatologie und Allergologie
Albert-Einstein-Allee 23
89081 Ulm


Head

Prof. Dr. Hartmut Geiger
Klinik für Dermatologie und Allergologie
Universität Ulm
James Franck-Ring 11c
89081 Ulm


Project 8

The role of thymus-epithelial cell progenitors in thymus aging

The cellular and molecular basis for premature thymus aging remains largely unknown. It seems evident that thymus involution is due to defects within the thymus (intrinsic) and is not a systemic (extrinsic) effect. This intrinsic defect does not focus directly on thymocytes, but rather on thymus epithelial cells (TEC), which form the thymus structure. The generation, preservation and potential regeneration of functional TEC could be clarified by the presence and activity of TEC stem or progenitor cells in the thymus. Additionally, the loss of such cells or their activity or perturbation of TEC differentiation might be associated with thymus involution. This project aims to address these questions. In preliminary experiments we have established a TEC colony assay, which will be used to analyze the dependence of TEC precursor cell activity on thymus age and thymus involution using a TEC-specific reporter murine model. These experiments will yield novel information concerning the potential contribution of thymus epithelial progenitor cells to thymus aging.

Chief Investigator

Prof. Dr. Hans-Reimer Rodewald
Director
Institute for Immunology
University Hospital Ulm
Albert-Einstein-Allee 11
89070 Ulm
Germany

Phone: +49 (0)731/500-65200
Cell: +49 (0)173/3492480
Fax: +49 (0)731/500-65202
hans-reimer.rodewald[at]uni-ulm.de

References

List of publications from:
Hans-Reimer Rodewald
>> Pubmed


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